Disarmament experts from the international chemical weapons watchdog have begun destroying Syria's arsenal, a monitoring official has said.
The operation is being carried out by a team from the Organisation for the Prohibition of Chemical Weapons (OPCW).
The mission was established under a UN resolution passed after agreement between Russia and the US.
The resolution followed international outrage at a chemical weapons attack near Damascus in August.
In an interim report, UN chemical weapons inspectors confirmed that the nerve agent sarin had been used in the attack in Ghouta on the outskirts of the city on August 21.
It was estimated to have killed hundreds of people and was blamed by the United States and other Western powers on the regime of Bashar al-Assad. But he accuses Syrian rebels of being behind it.
"Today is the first day of destruction, in which heavy vehicles are going to run over and thus destroy missile warheads, aerial chemical bombs and mobile and static mixing and filling units," a source with the inspection operation told the French AFP news agency.
It is not clear at which of the 19 chemical weapons sites declared by the government Sunday's operation is taking place.
Destruction of the stockpile is not expected to be straightforward as some sites are in combat zones as Syria is still ravaged by civil war.
It is the first time the OPCW - based in the Hague - has been asked to destroy a chemical weapons armoury during a conflict.
The Syrian government gave details of its chemical weapons arsenal last month to the OPCW under the Russia-US agreement which also provided for Damascus to join the Chemical Weapons Convention.
That arsenal is thought to include more than 1,000 tonnes of sarin and the blister agent sulphur mustard among other banned chemicals.
Peace conference
Under the terms of the agreement between the US and Russia Syria's chemical weapons capability should be removed by the middle of 2014.
The speed with which the team has been able to reach the sites and start the process of destruction underlines the urgency of the mission, says the BBC's Anna Holligan in the Hague.
It was hoped that the new climate of co-operation would help bring about a wider conference in Geneva on ending the Syrian conflict.
UN-Arab League peace envoy Lakhdar Brahimi was quoted on French media on Sunday as saying he was encouraging all parties to come to Geneva in the second half of November but that peace talks were not a certainty.
Syrian President Bashar al-Assad has meanwhile suggested Germany could mediate to try to end the 30-month-long civil war.
Speaking to Germany's Der Spiegel magazine in an interview to be published on Monday, Mr Assad said he "would be delighted if envoys came from Germany".
But he stressed that Damascus would not negotiate with rebels unless they laid down their weapons.
Mr Assad again repeated his denial that his troops had used chemical weapons, blaming the rebels instead.
More than 100,000 people have died since the uprising began in 2011 and millions more have fled Syria.
U say? So fast? Dem go para ooo
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